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RESPIRATORY

NASAL
STEPS TO SUCCESS IN NOSE-TO-BRAIN DRUG DELIVERY
Reenal Gandhi and Gemma Budd consider the multiple hurdles associated with developing nasal drug delivery solutions, current understanding of the associated biology and the advantages of alternative device designs and state-of-the-art formulation practice.
PULMONARY
DELIVERING BIOLOGICS WITH SOFT MIST INHALERS – A MARKET POISED TO EXPAND
Philippe Rogueda discusses the inhalable biologics market, how the introduction of soft mist inhalers represents a significant opportunity for new and old therapeutics alike, and how the market is poised for a major expansion in therapeutic application, size and value.
Pharmapack Expert Panel on Patient-Centric Digital Health: Interview with Ben Cox, Team Consulting
INTERVIEW
Dr Ben Cox
Team Consulting
Pharmapack Expert Panel on Patient-Centric Digital Health: Interview with Ben Cox, Team Consulting
With Pharmapack returning to its traditional February timing in 2023, Team Consulting will be chairing a Day 1 expert panel discussion on patient-centric digital health solutions. Interviewed here, Ben Cox provides insight into trends the panel will discuss, lays out the current status of the industry with respect to digital health and considers what to look forward to at Pharmapack this year.
ADVANCEMENTS IN MONITORING ADHERENCE – A SMART MESH NEBULISER
CONNECTIVITY
Edgar Hernan Cuevas Brun
HCmed Innovations
ADVANCEMENTS IN MONITORING ADHERENCE – A SMART MESH NEBULISER
Edgar Hernan Cuevas Brun and Yuan-Ming Hsu consider patient adherence and the role HCmed Innovations’ AdheResp mesh nebuliser plays in monitoring adherence.
DIGITAL HEALTH: ADDRESSING MODERN HEALTHCARE CHALLENGES WITH SENSORS
CONNECTIVITY
Dr Haykel Ben Jamaa
Sensirion
DIGITAL HEALTH: ADDRESSING MODERN HEALTHCARE CHALLENGES WITH SENSORS
Haykel Ben Jamaa explores why modern society needs digital health and how it is organised and implemented, with a focus on sensing technologies empowering digital health technologies.
WHY ARE INHALATION DEVICES SO DIFFICULT TO DEVELOP?
PULMONARY
Dr Orest Lastow
Iconovo
WHY ARE INHALATION DEVICES SO DIFFICULT TO DEVELOP?
Orest Lastow discusses the challenges of developing inhalation products and how best to keep costs down and prevent project delays.
CREATING A PLATFORM FOR NEBULISATION OF A WIDE RANGE OF DRUG TYPES AND FORMULATIONS
EARLY INSIGHT
Dr Elijah Nazarzadeh
Nebu~Flow
CREATING A PLATFORM FOR NEBULISATION OF A WIDE RANGE OF DRUG TYPES AND FORMULATIONS
Elijah Nazarzadeh and John Pritchard introduce Nebu~Flow – a novel class of nebuliser technology that represents a major step in the ability to deliver drugs efficiently to the lungs. overcoming the limitations of current systems and unlocking the potential of the inhalation route, including for systemic delivery.
A ROADMAP FOR DRUG-NEBULISER COMBINATION PRODUCT DEVELOPMENT
PULMONARY
Edgar Hernan Cuevas Brun
HCmed Innovations
A ROADMAP FOR DRUG-NEBULISER COMBINATION PRODUCT DEVELOPMENT
Edgar Hernan Cuevas Brun and Yuan-Ming Hsu lay out HCmed Innovations’ roadmap for the development of drug-nebuliser combination products.
AN AIRLESS SPRAY NOZZLE TO PRODUCE A FINE AND SOFT MIST
PULMONARY
Dr Claire Authesserre
Eveon
AN AIRLESS SPRAY NOZZLE TO PRODUCE A FINE AND SOFT MIST
Claire Authesserre and Florian Corne discuss the current challenges faced by the topical spray-based delivery of therapeutics and how EVEON’s Ad-Mist™ spray nozzle overcomes these challenges to harness the potential of this delivery route.
GETTING A GRIP ON FRICTION – A CRUCIAL CONSIDERATION FOR INHALER DESIGN
PULMONARY
Bryan Deacon
Celanese
GETTING A GRIP ON FRICTION – A CRUCIAL CONSIDERATION FOR INHALER DESIGN
Bryan Deacon discusses the importance of considering friction when developing a new inhaler design, providing an overview of some of the basic considerations friction raises, as well as highlighting how optimising friction early with the aid of a materials expert can reduce risk, lower cost and lead to a better product overall.
EXPLORING NEW IN VITRO TESTS TO DEMONSTRATE BIOEQUIVALENCE IN INHALATION PRODUCTS
PULMONARY
Lynn Jordan
Proveris Scientific
EXPLORING NEW IN VITRO TESTS TO DEMONSTRATE BIOEQUIVALENCE IN INHALATION PRODUCTS
Proveris Scientific looks at recent advances in in vitro testing in inhalation products to demonstrate bioequivalence and discusses the company’s INVIDA platform that replicates human usage of the device.
EXPANDING THE DESIGN OF CHARACTERISATION STUDIES FOR ACCURATE HANDLING-ERROR ASSESSMENT
EXPERT VIEW
Dr Yannick Baschung
EXPANDING THE DESIGN OF CHARACTERISATION STUDIES FOR ACCURATE HANDLING-ERROR ASSESSMENT
Yannick Baschung discusses the importance of a comprehensive and accurate assessment of patient handling errors when it comes to inhaled product development.
THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION
EXPERT VIEW
James Silk
THE INFLUENCE OF UNCERTAINTY ON CHEMICAL CHARACTERISATION
James Silk discusses the importance of accounting for uncertainty when characterising the extractables profile of a medication, with particular reference to the ISO 10993 standard.
POWDER CHARACTERISATION FOR DPI PERFORMANCE IN CAPSULE-BASED INHALERS
PULMONARY
Dr Salvatore Pillitteri
Granutools
POWDER CHARACTERISATION FOR DPI PERFORMANCE IN CAPSULE-BASED INHALERS
Salvatore Pillitteri, Aurélien Neveu and Sarah Zellnitz-Neugebauer discuss the analysis of three powder blends of salbutamol sulphate with distinct lactose grades, using tapped density and rotating drum methods.
ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE
INDUSTRIALISATION
Drew Jelgerhuis
Scherdel Medtec North America
ENGINEERING EXPERTISE: DESIGN FOR EXCELLENCE
Drew Jelgerhuis looks at how a design-for-excellence (DFX) systematic approach can help manufacturers achieve their objectives.
HIGH-PRECISION INJECTION MOULDS FOR INHALERS: CHALLENGES AND SOLUTIONS
INDUSTRIALISATION
Rob Doorakkers
IGS GeboJagema
HIGH-PRECISION INJECTION MOULDS FOR INHALERS: CHALLENGES AND SOLUTIONS
Rob Doorakkers and Erwin van Huijksloot discuss the challenges and solutions of engineering and manufacturing high-precision injection moulds for inhalers.
CLIPhaler – INHALATION DEVICE DESIGN REDUCED TO THE MAXIMUM
EARLY INSIGHT
Dr Klaus-Dieter Beller
CLIPhaler – INHALATION DEVICE DESIGN REDUCED TO THE MAXIMUM
Klaus-Dieter Beller discusses the advantages of the inhalation route of administration, how his principle of design simplicity has informed the design of novel inhalation devices and introduces CLIPhaler, his latest and simplest device.
THE INNOVATIONS TACKLING CHALLENGES & MAXIMISING OPPORTUNITIES IN INHALATION
EXPERT VIEW
Marco Franza
THE INNOVATIONS TACKLING CHALLENGES & MAXIMISING OPPORTUNITIES IN INHALATION
Marco Franza and Nadine Khoury look at how the latest digital technologies, manufacturing techniques and packaging materials are combining to take the manufacture of inhalers to a new level.
TAKING THE STING OUT OF VACCINES
EXPERT VIEW
Dr Heather Jameson
TAKING THE STING OUT OF VACCINES
Heather Jameson, Juliette Ngan and Omar Shah discuss the potential advantages and challenges of intranasal and inhaled vaccines in the context of global respiratory pandemics.
SOLVING COMPLEX FORMULATION & DELIVERY CHALLENGES FOR INTRANASAL DRUGS
EXPERT VIEW
Dr Paul Kippax
SOLVING COMPLEX FORMULATION & DELIVERY CHALLENGES FOR INTRANASAL DRUGS
Paul Kippax discusses the analytical techniques used for in vitro characterisation of nasal sprays, and how their use can accelerate and de-risk both innovator and generic nasal drug development.
NASAL DELIVERY – A GALAXY NOT SO FAR AWAY… A BRIEF MARKET HISTORY OF THE NASAL DELIVERY LANDSCAPE
EXPERT VIEW
Mark Ignaczak
NASAL DELIVERY – A GALAXY NOT SO FAR AWAY… A BRIEF MARKET HISTORY OF THE NASAL DELIVERY LANDSCAPE
Mark Ignaczak provides an insight into the history of nasal drug delivery and looks at the advantages of the nasal delivery route.
MAKING SUSTAINABILITY BY DESIGN THE LINTEL OF SUSTAINABLE INHALER DEVELOPMENT
SUSTAINABILITY
Phil Seeney
PA Consulting
MAKING SUSTAINABILITY BY DESIGN THE LINTEL OF SUSTAINABLE INHALER DEVELOPMENT
Phil Seeney, Philip Winkworth and Craig Nelson provide an insight into sustainability developments in the pharmaceutical industry, with a focus on inhalables.
CONSIDERING THE SUSTAINABILITY IMPACT OF CONNECTED INHALERS IN THE TREATMENT OF ASTHMA
SUSTAINABILITY
Dr Iain Simpson
Phillips-Medisize
CONSIDERING THE SUSTAINABILITY IMPACT OF CONNECTED INHALERS IN THE TREATMENT OF ASTHMA
Iain Simpson and Vinith Bhandari consider the sustainability impact of device connectivity specific to asthma inhalers through the reduction of greenhouse gas emissions.
SUSTAINABILITY MEASURES ARE THE KEY TO MEETING ESG COMMITMENTS
SUSTAINABILITY
Matthias Birkhoff
Aptar Pharma
SUSTAINABILITY MEASURES ARE THE KEY TO MEETING ESG COMMITMENTS
Matthias Birkhoff and Christophe Marie discuss the advances Aptar Pharma has made in delivering on its sustainability objectives.
INDUSTRIALISATION AND SCALE-UP OF DRUG DELIVERY DEVICES
INDUSTRIALISATION
Dr Barry McDermott
West Pharmaceutical Services
INDUSTRIALISATION AND SCALE-UP OF DRUG DELIVERY DEVICES
Barry McDermott and Shari Krusniak look at the manufacturing processes involved in bringing a new drug delivery system and formulation to market.
HOLISTIC DEVELOPMENT & INDUSTRIALISATION OF DRUG DELIVERY DEVICES & COMBINATION PRODUCTS
INDUSTRIALISATION
Mark Tunkel
Nemera
HOLISTIC DEVELOPMENT & INDUSTRIALISATION OF DRUG DELIVERY DEVICES & COMBINATION PRODUCTS
Mark Tunkel and Niyati Sapatnekar discuss Nemera’s holistic approach to development and industrialisation.
A GAME CHANGER FOR HIGH-RISK MEDICATIONS VIA AN INTRANASAL DELIVERY PLATFORM
CONNECTIVITY
Marcel Botha
Aero Pump
A GAME CHANGER FOR HIGH-RISK MEDICATIONS VIA AN INTRANASAL DELIVERY PLATFORM
Marcel Botha, Andreas Bilstein, Houssam Elghobary and Rouven Kraus discuss the benefits of the Validose digital health platform for the safe delivery of high-value and/or high-risk products.
THE SMART INHALER REVOLUTION: ARE WE THERE YET?
CONNECTIVITY
Dr Mark Allen
Cambridge Design Partnership
THE SMART INHALER REVOLUTION: ARE WE THERE YET?
Mark Allen, David Blakey and Karla Sanchez discuss the benefits of smart inhalers and how they could influence the commercialisation of respiratory drugs in the future.
ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY
INJECTION
Bill Welch
Picocyl
ADVANCEMENTS AND EVOLUTION OF POWER SOURCES IN DRUG DELIVERY
William Welch considers the evolution of compressed gas alternatives to spring power for single-use drug delivery devices.
ARE GOVERNMENTS BANNING THE MOST ENVIRONMENTALLY FRIENDLY INHALER?
EXPERT VIEW
Rob Udale
ARE GOVERNMENTS BANNING THE MOST ENVIRONMENTALLY FRIENDLY INHALER?
Rob Udale, Catriona Eldridge and Omar Shah assess the assertion that pMDIs are the most environmentally damaging of the available pulmonary drug delivery device archetypes, and explore some of the intricacies not accounted for in the public discourse surrounding pMDIs.
SMART SOLUTIONS TO REDUCE CARBON FOOTPRINT
SUSTAINABILITY
Rob Doorakkers
IGS GeboJagema
SMART SOLUTIONS TO REDUCE CARBON FOOTPRINT
Rob Doorakkers and Geert van Amstel discuss why the company decided to become carbon neutral, how it is working to make injection moulding more sustainable and how the organisation is minimising its impact on the environment.
DESIGNING DRUG DELIVERY DEVICES TO MEET EMERGING NEEDS AND SUSTAINABILITY GOALS
SUSTAINABILITY
Dr Pierre Moulinie
Covestro LLC
DESIGNING DRUG DELIVERY DEVICES TO MEET EMERGING NEEDS AND SUSTAINABILITY GOALS
Pierre Moulinié, Isaac Platte and Lauren Zetts discuss how polycarbonate-based materials deliver value to emerging drug delivery devices.
HOW CAN THE PHARMA INDUSTRY PREPARE FOR NEW pMDI PROPELLANTS?
SUSTAINABILITY
Nick Atkinson
Recipharm
HOW CAN THE PHARMA INDUSTRY PREPARE FOR NEW pMDI PROPELLANTS?
Nick Atkinson looks at the changes that are set to hit pressurised metered dose inhaler manufacturing as new propellants are introduced and how pharma companies can prepare for the switch.
CAPSULES: CLASSIC DRUG DELIVERY FORM HOLDS POTENTIAL FOR SUSTAINABLE DELIVERY
EXPERT VIEW
Dr Jnanadeva Bhat
CAPSULES: CLASSIC DRUG DELIVERY FORM HOLDS POTENTIAL FOR SUSTAINABLE DELIVERY
Jnanadeva Bhat and Anita Solanki discuss the role that hard capsules are able to play in delivering a more sustainable pharmaceutical industry, both as an oral solid dosage form and in dry powder inhalers.
INVESTIGATING THE PROPELLANT PATHWAYS LEADING TO A SUSTAINABLE FUTURE FOR MDIS
SUSTAINABILITY
Chris Baron
Aptar Pharma
INVESTIGATING THE PROPELLANT PATHWAYS LEADING TO A SUSTAINABLE FUTURE FOR MDIS
Chris Baron and Jag Shur discuss the various dynamics involved in realising the full potential of MDIs to deliver both improved environmental performance and even better patient outcomes.
NANOTECHNOLOGY: A NEXT-GENERATION TOOL FOR PULMONARY & NASAL DELIVERY
EXPERT VIEW
Frédérique Bordes-Picard
NANOTECHNOLOGY: A NEXT-GENERATION TOOL FOR PULMONARY & NASAL DELIVERY
Frédérique Bordes-Picard looks at the role of nanotechnology in the nasal and pulmonary routes of drug delivery and explains how nanoparticle explains how nanoparticle solutions could transform patient comfort and compliance.
WAITING WITH BATED BREATH – WHAT’S IN STORE FOR 2022
EXPERT VIEW
Rob Udale
WAITING WITH BATED BREATH – WHAT’S IN STORE FOR 2022
Rob Udale and Heather Jameson discuss the exciting developments taking place in the design of inhalation devices and share their predictions for the top five inhalation trends to watch as 2022 unfolds, and beyond.
PERSONALISED AEROSOL LOADING AND MANAGEMENT (PALM): A HANDHELD DEVICE FOR AEROSOL DRUG DELIVERY
EARLY INSIGHT
Dr Jason Brenker
Monash University
PERSONALISED AEROSOL LOADING AND MANAGEMENT (PALM): A HANDHELD DEVICE FOR AEROSOL DRUG DELIVERY
Jason Brenker, Tuncay Alan and Daniela Traini introduce the PALM – Personalised Aerosol Loading and Management – device, a unique, advanced drug delivery device enabling personalised delivery of aerosols to improve the efficacy of inhaled medications and patient compliance.
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