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MICRONEEDLES

EXPERT VIEW
THE NEXT GENERATION OF MICRONEEDLES: HARNESSING A BILLION YEARS OF EVOLUTION
Gabriel Villar and Ethan Miller consider examples of nature’s solutions to four challenges faced by microneedles for drug delivery. For each challenge, the authors explain how a natural organism has tackled it and what lessons may be directly applied to microneedle design.
UNLOCKING THE POTENTIAL OF MICRONEEDLE TECHNOLOGY
MICRONEEDLES
Bart van Oorschot
uPATCH
UNLOCKING THE POTENTIAL OF MICRONEEDLE TECHNOLOGY
Bart van Oorschot and Maarten Smit discuss the exciting potential of microneedle-based delivery systems to transform the drug delivery industry, the challenges faced by this technology and how the use of an applicator may be the way to overcome them.
3D-PRINTED HOLLOW MICRONEEDLES: A NEW FRONTIER FOR TRANSDERMAL DRUG DELIVERY
EARLY INSIGHT
Dr Dimitrios Lamprou
Queen's University Belfast
3D-PRINTED HOLLOW MICRONEEDLES: A NEW FRONTIER FOR TRANSDERMAL DRUG DELIVERY
Dimitrios Lamprou and Essyrose Mathew discuss the potential of 3D-printed hollow microneedles for transdermal drug delivery.
SERITECH LEVERAGES FAST-DETACHING, DISSOLVING MICRONEEDLE FOR TRANSDERMAL DRUG DELIVERY
EARLY INSIGHT
Mr Richard Joye
SeriTech
SERITECH LEVERAGES FAST-DETACHING, DISSOLVING MICRONEEDLE FOR TRANSDERMAL DRUG DELIVERY
Richard Joye and Tim Morch discuss the advantages of using dissolvable microneedles for the delivery of vaccines, particularly in regards to storage and transport, and introduce SeriTech’s fast-detaching dissolvable microneedle technology.
WHY THE CONSISTENT CHALLENGES SURROUNDING MAPS ARE DISSOLVING FAST
MICRONEEDLES
Dr Sebastian Braun
LTS
WHY THE CONSISTENT CHALLENGES SURROUNDING MAPS ARE DISSOLVING FAST
Sebastian Braun discusses the current state of microneedle-based transdermal drug delivery, covering available microneedle delivery methods, the US FDA’s current stance on microneedle technologies and LTS’s microarray patch (MAP) system and the possibilities it represents.
MICRONEEDLES FOR INTRADERMAL DELIVERY OF CANCER VACCINES
MICRONEEDLES
Dr John Vasilakos
Kindeva Drug Delivery
MICRONEEDLES FOR INTRADERMAL DELIVERY OF CANCER VACCINES
John Vasilakos discusses the immuno-oncology market. He examines the role of cancer vaccines in supplementing other immuno-oncology therapies, as well as the value of delivering cancer vaccines intradermally.
AN ANGLED MICRONEEDLE PATCH FOR ENHANCED DRUG AND VACCINE DELIVERY
EARLY INSIGHT
Dr Nicky Bertollo
Latch Medical
AN ANGLED MICRONEEDLE PATCH FOR ENHANCED DRUG AND VACCINE DELIVERY
Nicky Bertollo, Ronan Byrne and Andrew Muddle introduce Pharma Latch – a user-centric angled microneedle patch technology. They discuss its key benefits, such as dramatically increased payload potential, precision, low cost and variable patch-wear times, and highlight how Pharma Latch has the potential to overcome many of the limitations of existing routes of administration for therapeutics and vaccines.
INTERVIEW WITH AARON MANN, CHIEF EXECUTIVE OFFICER, KINDEVA
INTERVIEW
Aaron Mann
INTERVIEW WITH AARON MANN, CHIEF EXECUTIVE OFFICER, KINDEVA
In this exclusive interview with ONdrugDelivery, Aaron Mann discusses how Kindeva is positioned to move forward as a major CDMO specialising in inhalation and transdermal dosage forms, having been formed from 3M’s drug delivery in May 2020. We also cover the impact of Covid-19, environmental sustainability, and current challenges faced by the pharmaceutical industry.
VAXESS RECEIVES BARDA CONTRACT FOR COVID-19 + SEASONAL FLU VACCINE IN ITS SMART-RELEASE MICRONEEDLE PATCH
COVID-19 NEWS
VAXESS RECEIVES BARDA CONTRACT FOR COVID-19 + SEASONAL FLU VACCINE IN ITS SMART-RELEASE MICRONEEDLE PATCH
Vaxess Technologies is to receive US BARDA funding to demonstrate the feasibility of its MIMIX microneedle patch technology for a COVID-19 vaccine, with the aim of designing and developing a “combination seasonal protection patch”, incorporating COVID-19 + seasonal influenza protection.
NanoPass Sharing Microneedle Device with Pharma Partners for COVID-19 Vaccine
COVID-19 NEWS
NanoPass Sharing Microneedle Device with Pharma Partners for COVID-19 Vaccine
NanoPass is sharing its proprietary MicronJet microneedle device with vaccine and immunotherapy companies to help in the efforts to develop a safe, effective and affordable vaccine against SARS-COV-2, novel coronavirus.
SKIN-MOUNTABLE FLEXIBLE NEEDLE PATCH FOR MINIMALLY INVASIVE CONTROLLED DRUG DELIVERY
EARLY INSIGHT
Dr Chi Hwan Lee
Weldon School of Biomedical Engineering
SKIN-MOUNTABLE FLEXIBLE NEEDLE PATCH FOR MINIMALLY INVASIVE CONTROLLED DRUG DELIVERY
Chi Hwan Lee and Eun Kwang Lee introduce a skin-mountable flexible needle patch and discuss its applications in non-invasive drug delivery applications.
DISSOLVABLE MICRONEEDLES: APPLICATIONS AND OPPORTUNITIES
SKIN
Dr Jung Dong Kim
Raphas
DISSOLVABLE MICRONEEDLES: APPLICATIONS AND OPPORTUNITIES
Jung Dong Kim and Do Hyeon Jeong discuss dissolvable microneedle technology and its myriad uses.
AN INTRADERMAL PLATFORM BUILT FOR INDUSTRY AND PATIENTS
EARLY INSIGHT
Dr Moe Wehbe
Microdermics
AN INTRADERMAL PLATFORM BUILT FOR INDUSTRY AND PATIENTS
Moe Wehbe, Iman Mansoor and Sahan Ranamukha discuss the potential of intradermal injection for modern medicines and its advantages over the subcutaneous route.
SIMPLIFIED DRUG AND VACCINE DELIVERY USING MICRON’S MICRONEEDLE PATCH
EARLY INSIGHT
Dr Mark Prausnitz
Micron Biomedical
SIMPLIFIED DRUG AND VACCINE DELIVERY USING MICRON’S MICRONEEDLE PATCH
Devin V McAllister, Sebastien Henry and Mark Prausnitz introduce the company’s dissolving microneedle patch technology, which has global potential, including in the developing world, across a range of vaccine and therapeutic applications.
TERIPARATIDE MICRO-PATCH™: A SOLID MICRONEEDLE PRODUCT NEARING CLINICAL TRIALS
SKIN
Dr Faz Chowhury
Nemaura Pharma
TERIPARATIDE MICRO-PATCH™: A SOLID MICRONEEDLE PRODUCT NEARING CLINICAL TRIALS
Faz Chowdhury details a Micro-Patch™ solid formulation of the parathyroid hormone analogue, teriparatide, for the treatment of osteoporosis.
VACCINE DELIVERY USING THE NEMAURA SOLID DOSE INJECTOR
MICRONEEDLES
David Scott
Nemaura Pharma
VACCINE DELIVERY USING THE NEMAURA SOLID DOSE INJECTOR
Joanne Broadhead and Karmen Cheung report an investigation into the delivery of two vaccines using Nemaura Pharma’s solid-dose injection technology.
THE RAPID EVOLUTION OF THE TRANSDERMAL DRUG DELIVERY INDUSTRY SPAWNS INNOVATION
MICRONEEDLES
Luis Tissone
Trelleborg
THE RAPID EVOLUTION OF THE TRANSDERMAL DRUG DELIVERY INDUSTRY SPAWNS INNOVATION
Luis Tissone outlines technological developments behind microneedle design including the use of advanced liquid silicone rubber (LSR) and two-component injection technology, and explores the advantages this route offers over traditional intramuscular routes.
THE CRITICALITY OF ADHESIVE SELECTION FOR OPTIMAL TRANSDERMAL DRUG DELIVERY SYSTEMS
TRANSDERMAL
Megan Greth
ARx
THE CRITICALITY OF ADHESIVE SELECTION FOR OPTIMAL TRANSDERMAL DRUG DELIVERY SYSTEMS
Megan Greth and Gozde Karabiyik discuss why selecting the right adhesive for body-worn drug delivery systems – be they transdermal patches or wearable injection devices or pumps – is critical for a successful outcome.
MICROBRISTLE APPLICATOR (MBA™) SYSTEMS FOR TOPICAL AND TRANSDERMAL DRUG APPLICATION
TRANSDERMAL
Pierre Michelet
GEKA Healthcare
MICROBRISTLE APPLICATOR (MBA™) SYSTEMS FOR TOPICAL AND TRANSDERMAL DRUG APPLICATION
Pierre Michelet, Karl Hartstock-Martin, and Moritz Beyhl present the innovative technology of microbristle applicators (MBA™) for a more precise and hygienic application within topical and transdermal treatment. MBA™ comprises a platform of moulded, pure plastic applicators with very fine bristles to apply liquid and semi-liquid formulations.
MEETING EVOLVING BIOLOGICS & SMALL MOLECULES NEEDS
MICRONEEDLES
Dr Lisa A Dick
MEETING EVOLVING BIOLOGICS & SMALL MOLECULES NEEDS
Lisa A Dick provides a run-down of the concept, design and development of the company’s microneedle drug delivery platform, both hollow and solid needle arrays, including recent clinical trials of the hollow-needle device.
Q&A: SUCCESSFUL MASS PRODUCTION OF AN INNOVATIVE DRUG DELIVERY TECHNOLOGY
MICRONEEDLES
Dr Jung Dong Kim
Raphas
Q&A: SUCCESSFUL MASS PRODUCTION OF AN INNOVATIVE DRUG DELIVERY TECHNOLOGY
Jung Dong Kim answers questions about the company, its capabilities, and the mass production of an innovative dissolving microstructure drug delivery technology.
HIGHLY CUSTOMISABLE HOLLOW POLYMER MICRONEEDLE SOLUTIONS
MICRONEEDLES
Dr Marion Sausse Lhernould
Novinject
HIGHLY CUSTOMISABLE HOLLOW POLYMER MICRONEEDLE SOLUTIONS
Marion Sausse Lhernould, Serge Tailler, Michel Deleers and Alain Delchambre present a hollow microneedle delivery device manufactured using a novel proprietary process.
DERMAL DELIVERY OF BIOLOGICS
MICRONEEDLES
Dr Richard Toon
Nemaura Pharma
DERMAL DELIVERY OF BIOLOGICS
Faz Chowdhury and Richard Toon describe one of the company’s key technologies for the delivery of biologics, the Micropatch™.
NOVEL TRANSDERMAL DELIVERY SYSTEMS FOR TREATMENT OF DIABETES
TRANSDERMAL
Dr Alan Smith
4P Therapeutics
NOVEL TRANSDERMAL DELIVERY SYSTEMS FOR TREATMENT OF DIABETES
Alan Smith outlines the stages of Type 2 diabetes treatment, progressing to extenatide and insulin injections, and makes the case, using clinical data, for the transdermal route as a viable alternative to injections.
YOUR SOLUTION FOR SUCCESSFUL INTRADERMAL DELIVERY
MICRONEEDLES
Dr Paul Vescovo
Debiotech
YOUR SOLUTION FOR SUCCESSFUL INTRADERMAL DELIVERY
Paul Vescovo and Laurent-Dominique Piveteau discuss the design of the Debioject™ microneedle device and inserter, and its applications, particularly in intradermal delivery of vaccines.
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